AI Investors in Manchester (2026): Who Is Backing Early-Stage Startups
The investors backing early-stage AI startups in Manchester in 2026: what each one invests in, cheque sizes and the AI startups they have backed.

The main Manchester investors backing early-stage AI startups in 2026 include PXN Ventures, Northern Gritstone, DSW Ventures, EHE Ventures and River Capital's fund:AI, covering everything from pre-seed to Series A.
Researched and written by Zeeshan Ali at Platvix. Updated October 2026.
TL;DR
- Raising pre-seed? PXN Ventures runs the PraeSeed programme, and DSW Ventures invests from £100,000 before Series A.
- University spinout? Northern Gritstone partners with the universities of Leeds, Liverpool, Manchester and Sheffield and invests in science and technology spinouts.
- Building an AI-first company? EHE Ventures in Manchester backs AI-first startups from pre-seed to Series A, and River Capital's fund:AI backs Northern AI companies with revenue.
Pre-seed and seed AI investors in Manchester
PXN Ventures
A Manchester-based venture investor, part of PXN Group, which manages several funds for the North West.
- Invests in: pre-seed through its PraeSeed programme, and seed and later rounds through the Northern Powerhouse Investment Fund II and the GMC Life Sciences Fund
- Cheque size: £200,000 per company through PraeSeed (2026 cohort), and up to £5m through NPIF II
- AI startups backed: led the £5m seed round in Imperagen, a University of Manchester spinout using AI and quantum physics to engineer enzymes (May 2026), and the £3m seed round in Rightbrain AI, a Newcastle-founded AI agent company (May 2026)
- Latest fund: NPIF II – PXN Equity Finance, a £180m fund for the North West, launched March 2024 and extended by £80m in September 2026
- Website: pxnventures.co.uk
Northern Gritstone
A Manchester-based investment company that partners with the universities of Leeds, Liverpool, Manchester and Sheffield, investing in science and technology businesses.
- Invests in: deeptech and life sciences companies, with recent rounds from pre-seed (AmpliSi, March 2026) to a Series A extension (Optalysys, January 2026)
- AI startups backed: Imperagen, as an existing investor in its May 2026 seed round, and Literal Labs, a Newcastle University AI spinout whose £4.6m pre-seed round it co-led with Mercuri (June 2025)
- Latest fund: no fixed fund. It invests from permanent capital of £382m, reached after a £20m close in April 2026
- Website: northern-gritstone.com
DSW Ventures
A Manchester-based venture capital firm, part of Dow Schofield Watts, that manages SEIS and EIS funds and often leads early rounds.
- Invests in: early-stage UK companies before Series A, typically as a single or lead investor
- Cheque size: £100,000 to £1m per investment, in rounds of £300,000 to £3m
- AI startups backed: Nexco.ai, a London-based startup building AI agents for executive search firms (pre-seed, May 2026)
- Website: dsw.vc
EHE Ventures
A Manchester-based investor, part of EHE Group, running an (S)EIS fund that backs only AI-first UK startups, with technical support from its own venture studio.
- Invests in: AI-first UK businesses at pre-seed, seed and Series A
- AI startups backed: eight in its first cohort, including Deltabase, Fotenix, Peppercorn AI and Spotlight Pathology
- Latest fund: (S)EIS AI Growth Fund, aiming to deploy £15m in total, which opened a second £1.5m raise in July 2026
- Website: ehe.ai
River Capital (fund:AI)
A Liverpool-based fund manager running the North of England's first dedicated AI fund, structured as an EIS fund and open to companies across the North.
- Invests in: EIS-eligible companies in the North that use AI, machine learning or data science and have passed £250,000 in revenue
- Cheque size: typically £500,000 to £1m at first, and up to £2m across several rounds
- AI startups backed: Mojo CX, a Manchester contact-centre AI company, and £550,000 into Deltabase, a Liverpool competitor intelligence platform (December 2025)
- Website: rivercapitaluk.com
Also worth knowing
Manchester Angels, an angel network, has recently backed AI sales startup Doris Labs and Manchester cyber security startup Ghost Shift (October 2026). IQ Capital, a Cambridge deep tech investor, is also an investor in Imperagen.
FAQ
Is there an AI-only investor in Manchester?
Yes. EHE Ventures, based in Manchester, runs an (S)EIS fund that backs only AI-first startups from pre-seed to Series A. River Capital's fund:AI, managed from Liverpool, invests in Northern companies using AI, machine learning or data science that have passed £250,000 in revenue.
Who invests at pre-seed in Manchester?
PXN Ventures runs PraeSeed for pre-seed founders across the North, DSW Ventures invests from £100,000 before Series A, and EHE Ventures backs AI-first startups from pre-seed. Northern Gritstone has also led recent pre-seed rounds.
How were these investors chosen?
We included investors based in or active in Manchester that invest at pre-seed, seed or Series A, focus on AI or have backed AI startups, and have announced a fund or deal recently. Every fact links to the firm's own announcement or to business press.
How do I find which Manchester investors fit my startup?
Platvix is an investment intelligence platform for founders. It supports your fundraising journey by helping you refine your pitch deck and find the capital options most relevant to your startup, based on what each investor says it backs and what it has done recently.
Where to go from here
- AI investors in London
- AI investors in the North East
- Browse our pre-seed investor list
- How to get warm investor introductions without a network
- The 10 slides your pre-seed pitch deck needs
- What investors look for in AI startups
Find the Manchester investors most likely to back you
Manchester has funds, angel networks and public money for early-stage startups, so the hard part is knowing which ones fit your startup. Platvix researches which investors are likely to back a company like yours, based on what each one says it invests in and what it has been doing lately.
- Investor research across each firm's stated thesis, recent deals and fund announcements, kept up to date
- A targeted investor list built against your startup's stage, sector and location
- Deck analysis that reads your pitch the way an investor would
- Claims verification that checks the numbers in your deck before an investor does
Run that research on your own startup before you start sending your deck.
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If you run one of these funds and something has changed, get in touch.
Tags
- Investors
- AI Startups
- UK Fundraising
- Pre-seed
- SEIS
About the author
Zeeshan Ali, Co-Founder
Co-founder at Platvix, building an investment intelligence platform and the ecosystem around it so founders become investment-ready faster and VCs make stronger decisions. I focus on operations, partnerships, and community building, turning strategy into execution through programmes, processes, and founder support.